Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation
نویسندگان
چکیده
منابع مشابه
Testing for Ancient Selection Using Cross-population Allele Frequency Differentiation.
A powerful way to detect selection in a population is by modeling local allele frequency changes in a particular region of the genome under scenarios of selection and neutrality and finding which model is most compatible with the data. A previous method based on a cross-population composite likelihood ratio (XP-CLR) uses an outgroup population to detect departures from neutrality that could be ...
متن کاملTesting for ancient selection using cross-population allele
A powerful way to detect selection in a population is by modeling local allele frequency changes in a 7 particular region of the genome under scenarios of selection and neutrality, and finding which model is 8 most compatible with the data. Chen et al. [1] developed a composite likelihood method called XP-CLR 9 that uses an outgroup population to detect departures from neutrality which could be...
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Balancing selection occurs when multiple alleles are maintained in a population, which can result in their preservation over long evolutionary time periods. A characteristic signature of this long-term balancing selection is an excess number of intermediate frequency polymorphisms near the balanced variant. However, the expected distribution of allele frequencies at these loci has not been exte...
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ژورنال
عنوان ژورنال: Genetics
سال: 2015
ISSN: 1943-2631
DOI: 10.1534/genetics.115.178095